Exploring the Potential Role of C1-Esterase Inhibitor in Preventing Heart Transplant Graft Rejection

Abstract

Heart transplantation is considered the standard therapy for patients with end-stage heart failure who do not respond to treatment with drugs or devices. Dr. Christian Barnard performed the first heart transplant surgery in South Africa in December 1967. Since then, significant advancements have been made in the use of immunosuppressive drugs and monitoring techniques to detect and prevent post-transplant complications, leading to improved patient survival after surgery. This article discusses the potential of C1 esterase inhibitors in preventing heart transplant rejection and improving survival for end-stage heart failure patients.